Love & Loss follows two surprisingly strong women: Karen Crespo & Nicole Evans. Both women are vibrantly physically disabled; however, Nicole was born disabled while Karen became disabled later in life. There is a tremendous difference between being born with a disability and becoming disabled later. Nicole has had the past 30 years to cope with and learn to embrace her disability while Karen had deal with both the physical and emotional trauma almost overnight. Despite their trials, these women are taking steps to find love in their lives. Through the observation of the dating lives of theirs, this film explores the challenging and often unconventional intimate relationships of physically-impaired individuals, as well as how those individuals define and live their lives within the context of their disabilities.